Fig. 5.

Knockout of ROR1 alters the biodistribution of tumor EVs in mice. A Schematic representation of the biodistribution experiments. The figure was created with BioRender.com B + C Exemplary ex vivo FRI images (B) of mice organs 24 h after the injection of DiR-labeled 4T1 wildtype (WT) or ROR1 knockout (ROR1-KO) EVs and corresponding quantification of the ratio of mean signal intensities organ to muscle (C) for selected organs harboring fluorescent signals (mean ± SD). Significance was tested with a one-sided studen’t t test