Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 10;11:111. doi: 10.1186/s40478-023-01609-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Increased ITGA5 expression correlates with aggressive phenotype of Group 3 MB. (A)ITGA5 mRNA levels and (B) flow cytometric evaluation of cell surface levels of ITGA5 in human neural stem cells (hNSCs), as well as primary and matched-recurrent MB lines. Changes in (C) proliferation and (D) self-renewal capacity of recurrent Group 3 MB cells with (ITGA5+) and without (ITGA5-) ITGA5 presenting on the cell surface. Fraction of self-renewing cells in (E) HD-MB03-Re and (F) SU_MB002-Re post flow based on ITGA5 presentation on the cell surface. Bars represent mean of at least three technical replicates, with the exception of Fig. 2B with only one value. Bars represent mean of at least three technical replicates. *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.0001, ****p ≤ 0.00001; unpaired t-test or one-way ANOVA with Sidak’s method for multiple comparisons