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. 2023 Jul 10;11:111. doi: 10.1186/s40478-023-01609-7

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — In vitro effects of ITGA5 KD in MB cell lines. (A) Microscopic images demonstrating phenotypic changes post lentivector mediated KD of ITGA5 in representative recurrent Group 3 MB. Changes in (B) proliferation, (C) self-renewal, and (D-G) frequency of self-renewing cells of ITGA5 KD, compared to control lentivector in hNSC and recurrent Group 3 MB cell cultures. Bars represent mean of at least three technical replicates. Control samples (shGFP) normalized to 1.0. Bars represent mean of at least three technical replicates. *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.0001, ****p ≤ 0.00001; unpaired t-test or one-way ANOVA with Sidak’s method for multiple comparisons