Table 2.

Changes in iron-metabolism indices after initiation of roxadustat

Time	Ferritin (ng/mL)	SI (umol/L)	TIBC (umol/L)	UIBC (umol/L)	TS (%)	STfR (mg/L)	Hepcidin (ng/L)
Baseline (M0)	72.96 ± 14.16	15.72 ± 6.21	56.70 ± 10.83	41.49 ± 14.00	27.85 ± 12.20	38.46 ± 7.75	116.12 ± 17.46
M1	65.69 ± 12.00	16.63 ± 7.64	54.59 ± 8.65	37.97 ± 12.35	31.62 ± 15.82	41.63 ± 7.57	86.72 ± 16.97
M3	55.54 ± 13.73	15.47 ± 5.23	48.93 ± 12.97	33.46 ± 13.92	33.58 ± 14.99	50.18 ± 7.73	78.86 ± 15.90
F value	10.73	0.489	5.906	3.721	1.582	18.68	1034.523
P value	< 0.001	0.602	0.005	0.032	0.218	< 0.001	< 0.001

M0: before roxadustat; M1: 1 month after initiation of roxadustat; M3: 3 months after initiation of roxadustat (end of study)