Table 1.

Profiles depending on the kind of data hub organization

	Data hubs managed centrally	Data hubs having decentralized management
Actors	No peculiarities	May not a single data controller No data management strategy
Data aspects	Control the data stored Data from ‘general population’ Use ‘text’, ‘numbers’ Receive and store data from: single source, multiple sources	Data from ‘patient groups’, ‘general population’, ‘experimental settings’ Use ‘text’, ‘images’, ‘numbers’ Data stored in ‘XML’
Business processes	Data quality control SOPs Procedure to know who provides data​​	No peculiarities
ELSI aspects	Pseudonymized data Require legal approval	No peculiarities