Table 3.
Logistic Regression Analysis of Risk Factors for Carbapenem-Resistant K. pneumoniae Infection (n = 282)
| Univariate Analysis | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|
| Variables | OR | 95% CI | p | OR | 95% CI | p |
| Gender (male vs female) | 1.101 | 0.695–1.746 | 0.681 | |||
| Hypertension (yes vs no) | 1.264 | 0.659–2.424 | 0.482 | |||
| Chronic kidney disease (yes vs no) | 1.131 | 0.549–2.327 | 0.739 | |||
| Malignancy (yes vs no) | 7.708 | 3.654–16.260 | < 0.001 | 2.547 | 1.345–7.620 | 0.019 |
| Chronic pulmonary disease (yes vs no) | 1.184 | 0.642–1.855 | 0.168 | |||
| Neurological disorder (yes vs no) | 1.352 | 0.797–3.058 | 0.760 | |||
| Cardiovascular disease (yes vs no) | 2.562 | 1.220–5.378 | 0.013 | 1.977 | 1.126–3.795 | 0.032 |
| Diabetes mellitus (yes vs no) | 3.184 | 1.422–8.249 | 0.008 | 2.311 | 1.279–5.088 | 0.021 |
| Urinary catheter (yes vs no) | 1.728 | 0.810–4.455 | 0.137 | |||
| Central venous catheter (yes vs no) | 2.934 | 1.170–5.890 | 0.011 | 1.286 | 0.852–2.767 | 0.086 |
| Invasive mechanical ventilation (yes vs no) | 3.014 | 1.472–7.974 | 0.003 | 2.492 | 1.114–4.768 | 0.038 |
| Hemodialysis (yes vs no) | 1.351 | 0.641–3.915 | 0.096 | 1.084 | 0.473–2.034 | 0.271 |
| Total parenteral nutrition (yes vs no) | 1.841 | 1.137–2.769 | 0.034 | 1.177 | 0.809–1.921 | 0.122 |
| Tracheostomy (yes vs no) | 1.237 | 0.717–2.134 | 0.446 | |||
| Percutaneous endoscopic gastrostomy (yes vs no) | 1.122 | 0.503–1.674 | 0.589 | |||
| Surgical intervention (yes vs no) | 2.114 | 1.191–4.338 | 0.029 | 1.312 | 0.887–2.965 | 0.102 |
| History of hospitalization in the previous 6 months | 4.943 | 1.827–12.417 | 0.010 | 2.322 | 1.365–5.686 | 0.026 |
| Intensive care unit admission | 4.596 | 1.728–10.646 | 0.012 | 2.168 | 1.213–3.977 | 0.033 |
| Antibiotic use in previous 3 months | 3.488 | 1.562–9.650 | 0.024 | 1.362 | 0.586–4.028 | 0.092 |
| Cephalosporin use (yes vs no) | 5.114 | 1.601–17.872 | < 0.001 | 3.048 | 1.412–9.126 | 0.008 |
| Carbapenem use (yes vs no) | 4.450 | 1.309–12.313 | 0.002 | 2.646 | 1.204–8.312 | 0.014 |
| Glycopeptide use (yes vs no) | 2.102 | 0.791–9.566 | 0.128 | |||
| Quinolone use (yes vs no) | 6.531 | 1.818–19.036 | < 0.001 | 4.112 | 1.588–14.746 | 0.005 |
| Piperacillin-Tazobactam use (yes vs no) | 2.661 | 0.615–13.001 | 0.116 | |||
| Colistin use (yes vs no) | 1.960 | 0.405–8.238 | 0.131 | |||
| Linezolid use (yes vs no) | 1.579 | 0.381–7.205 | 0.282 | |||
Note: Bold indicates p values <0.05 are statistically significant.