Table 3.
KEGG Pathway Enrichment of Aberrantly Methylated Genes in Breast Cancer
| Pathway ID | Term | Number of Methylated Genes | P-value | Top Three Hypomethylated Gene |
|---|---|---|---|---|
| Hypomethylated genes | ||||
| hsa03010 | Ribosome | 7 | 0.000127759 | MRPL3P1/ RPL27A/RPS2P32 |
| hsa00510 | N-Glycan biosynthesis | 4 | 0.000710227 | DPM1/ RPN1/ ALG13 |
| hsa04910 | Insulin signaling pathway | 6 | 0.000874458 | RP6-24A23.6/ EIF4E/RHEB |
| hsa05203 | Viral carcinogenesis | 7 | 0.001245086 | H2BC17/ IKBKG/ MAD1L1 |
| hsa05230 | Central carbon metabolism in cancer | 4 | 0.00211821 | FLT3/ SLC16A3/ AKT1 |
| Hypermethylated genes | ||||
| hsa04330 | Notch signaling pathway | 2 | 0.00436209 | NCOR2/ KAT2A |
| hsa04923 | Regulation of lipolysis in adipocytes | 2 | 0.005826959 | GNAS/ RP6-24A23.6 |
| hsa05200 | Pathways in cancer | 4 | 0.008035652 | GNAS/ BCR/ NOS2P2 |
| hsa01100 | Metabolic pathways | 7 | 0.011269921 | NOS2P2/ PGS/ OXSM |
| hsa05032 | Morphine addiction | 2 | 0.01442998 | GNAS/ GNB1 |
Note: Genes are highlighted in italicized.