Table 4.
Functional Enrichment Analysis of Differentially Expressed Genes
| Term_Type | GO_ID | Description | p-value | Count | Top Three Upregulated Genes |
|---|---|---|---|---|---|
| Up-regulated genes | |||||
| Molecular Function (MF) | GO:0008094 | DNA-dependent ATPase activity | 8.40E-07 | 15 | RAD50/ BPTF/PBRM1 |
| GO:0004842 | Ubiquitin-protein transferase activity | 0.000045 | 35 | FBXO11/ FBXL13/RNF103 | |
| GO:0019787 | Ubiquitin-like protein transferase activity | 0.000068 | 36 | UBR3/ FBXL4/ TRIM9 | |
| Biological Process (BP) | GO:0060216 | Definitive hemopoiesis | 0.000012 | 7 | ZFP36L2/ TEK/TGFBR3 |
| GO:0030219 | Megakaryocyte differentiation | 0.000134 | 12 | CBFB/ GABPA/ KAT2B | |
| GO:0030099 | Myeloid cell differentiation | 0.000196 | 30 | ETS1/ IKZF1/ KMT2A | |
| Cellular Component (CC) | GO:0000785 | Chromatin | 0.00022 | 36 | KMT2E/ CENPF/RAD50 |
| GO:0016607 | Nuclear speck | 0.001656 | 27 | PUM1/ KMT2E/SMC5 | |
| GO:0008023 | Transcription elongation factor complex | 0.004677 | 7 | EPOP/ CTR9/AFF2 | |
| Down-regulated genes | |||||
| Molecular Function (MF) | GO:0003735 | Structural constituent of ribosome | 2.412E-15 | 31 | RPS11/ MRPL14/RPL38 |
| GO:0009055 | Electron transfer activity | 4.739E-06 | 15 | COX8A/ NDUFS6/CYBA | |
| GO:0016783 | Sulfurtransferase activity | 0.000035 | 5 | URM1/TSTD1/TRMU | |
| Cellular Component (CC) | GO:0044391 | Ribosomal subunit | 8.167E-14 | 32 | MRPS21/ RPL3L/RPS9 |
| GO:0015934 | Large ribosomal subunit | 2.840E-13 | 25 | RPL39/ RPL35/RPL34 | |
| GO:0022626 | Cytosolic ribosome | 1.47E-12 | 24 | RPL38/ RPS28/NAA10 | |
| Biological Process (BP) | GO:0006614 | SRP-dependent cotranslational protein targeting membrane | 4.993E-14 | 23 | ZFAND2B/ RPS11/RPL38 |
| GO:0006613 | Cotranslational protein targeting to membrane | 1.7E-13 | 23 | ZFAND2B/ UBA52/RPL41 | |
| GO:0019083 | Viral transcription | 4.71E-13 | 30 | TRIM31/ RPS28/POLR2E | |
Note: Genes are highlighted in italicized.