Figure 1.

SGLT1 is involved in the pathological process of myocardial injury. Under some conditions, such as high glucose, ischemia/reperfusion injury, and pressure and volume overload, the expression of SGLT1 are increased in vascular endothelial cells, cardiomyocytes, and cardiac fibroblasts, which participate in the pathological processes of myocardial damage such as mitochondrial dysfunction, oxidative stress, and fibrosis, ultimately leading to cardiac remodeling, systolic and diastolic dysfunction, and the occurrence of heart failure.