Table 1.

Summary of the effects of synaptic plasticity-related proteins on anxiety disorder

	Effects	References
mGluR1/5	Induction of LTP; regulation of AMPA receptor-dependent anxiety disorder	[17,21]
mGluR2/4/8	Induction of sex-dependent anxiety-like behavior	[24–27]
BDNF	Preserving the neuron, positive and negative effects in anxiety disorder	[34–39]
HCN1	Inhibiting BDNF–mTOR signaling and inducing anxiety disorder	[61]
PSD95	Inhibiting S-nitrosylation of AMPAR-interacting proteins and relieving anxiety-like behavior	[78]
Cntn1	Induction of microglia activation and anxiety-like behavior	[80]
Translocator protein	Involvement of neurosteroidogenesis and anxiety disorder by regulating GABAergic neurotransmission	[81]
TNFR1	Induction of the insertion of GluA1 receptor into BLA neurons, resulting in anxiety disorder	[82]
Interleukin 4	Improving the loss of neurons and relieving anxiety-like behavior	[83]