Table 4.
Effect of BTK Degradation on Cell Viability
| Compound | TMD8 Cells IC50 (nM)a |
Mino Cells IC50 (nM)a |
|---|---|---|
| PTD10 | 1.4 ± 0.2 (1.6) | 2.2 ± 0.8 (1.0) |
| GDC-0853 | 12.6 ± 1.4 (2.0) | 7.8 ± 2.2 (1.4)b |
| Pomalidomide | 187 ± 54 (0.8) | 20.8 ± 2.5 (2.0) |
| DD-03-171 | 5.1 ± 0.9 (1.5) | 10.9 ± 4.6 (0.6) |
| MT-802 | 12.0 ± 1.4 (1.6) | 100c |
| P13I | 15.0 ± 2.8 (1.2) | 10.4 ± 2.4 (3.7) |
a
Numbers in parentheses are the Hill slopes.
b
Cell viability was ~20% at the highest concentration of compound.
c
Cell viability was ~40% at the highest concentration of compound.