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. 2023 Jun 26;14:1196892. doi: 10.3389/fimmu.2023.1196892

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Copyright © 2023 Zhao, Ding, Tran, Chai and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Key TFs of regulon modules in melanoma cell subtypes. (A) Heatmap demonstrating the scaled expression of key transcription factors (TFs) in the regulon modules of the melanoma cell subtypes. (B) The dot plot shows the expression of these TFs. (C–E) The expression of STAT-1, IRF1, and FLI1 in pseudotime trajectories of subtypes of melanoma cells. (F–K) The violin plots and UMAP plots show the differential expression of STAT-1, IRF1, and FLI1 among subtypes of melanoma cells. (L–N) Kaplan-Meier survival plots of the high and low gene groups for STAT-1, IRF1, and FLI1. *P < 0.05, ****P < 0.0001.