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. 2023 Jun 26;14:1196892. doi: 10.3389/fimmu.2023.1196892

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Copyright © 2023 Zhao, Ding, Tran, Chai and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro experimental verification of TBX21. (A, B) The CCK-8 assay revealed a notable decrease in cell viability following the knockdown of TBX21. (C) The colony formation experiment demonstrated that cells with decreased TBX21 expression had a significantly lower number of colonies than the NC group. (D) The scratch-wound healing experiment showed that reduced TBX21 expression dramatically decreased the rate of wound healing. (E) EdU staining assay demonstrated that the downregulation of TBX21 hindered the proliferation of A375 and WM-115 cells relative to the NC group. (F) Transwell experiments showed that the downregulation of TBX21 drastically reduced the migration and invasion of A375 and WM-115 cells. *P < 0.05, **P < 0.01, ***P < 0.001.