Table 3.

Future Research: CAR T-Cells and Fertility

Theme	Specific question/comments	Suggestions for future
Standardized peri-CAR T-cell fertility guidance	• This is an important issue for younger patients • Identifying role for pre-CAR T-cell fertility assessment • Timing of pregnancy/fathering a child after CAR T-cell therapy • Does CRS have an impact on fertility? • Insurance coverage	Discussion within existing working groups and committees to create expert consensus guidelines for fertility preservation in CAR T-cell recipients.
Long-term outcomes	• Long-term data on fertility status • Fertility monitoring after single lymphodepletion therapy • What percentage get pregnant post CAR T-cells; pregnancy success	Establish multicenter collaborative to collect prospective fertility data from patients who receive CAR T-cell therapy and their eventual offspring, and compare to outcomes from patients who receive traditional therapies (i.e., chemotherapy, radiation, and stem cell transplantation).
Impact of CAR T-cells on developing fetus	• Are CAR T-cells passed through the placenta causing B-cell aplasia in the baby? • Outcomes of pregnancies/live births after CAR T-cells