Table 3.
Primary and secondary outcomes of the study
| Outcomes | Regional citrate (n = 38) | Anticoagulant-free (n = 38) | p value | |
|---|---|---|---|---|
| Primary outcomes | ||||
| 1st circuit life span, h | 44.9 (20.0, 72.0) | 14.3 (7.0, 22.0) | <0.001 | |
| Number of filters used within 72 h | 2.0 (1.0, 2.0) | 2.5 (2.0, 3.0) | 0.015 | |
| Reason for 1st circuit disconnection, n (%) | ||||
| Circuit clotting | 11 (28.9) | 27 (71.1) | 0.016 | |
| Schedule filter change | 22 (57.9) | 3 (7.9) | ||
| Switch to other dialysis mode | 5 (13.2) | 1 (2.6) | ||
| Vascular malfunction | 3 (7.9) | 0 (0) | ||
| Technical problem | 1 (2.6) | 1 (2.6) | ||
| Secondary outcomes | ||||
| Renal recovery, n (%) | 14 (36.8) | 13 (34.2) | 0.811 | |
| Length of ICU stay, days | 14.0 (6.0, 28.0) | 11.0 (7.0, 15.0) | 0.242 | |
| Mortality within | 14 days, n (%) | 9 (23.7) | 13 (34.2) | 0.312 |
| Mortality within | 28 days, n (%) | 13 (34.2) | 12 (31.6) | 0.807 |
| Complications, n (%) | ||||
| * Bleeding | 1 (2.6) | 1 (2.6) | 1.000 | |
| Citrate accumulation | 5 (13.2) | 0 (0) | 0.054 | |
| CRBSI | 1 (2.6) | 0 (0) | 0.493 | |
| Hypokalemia, <3.5 mEq/L | 21 (55.3) | 16 (42.1) | 0.359 | |
| Hypophosphatemia, <2.6 mg/dL | 15 (39.5) | 18 (47.4) | 0.643 | |
| Hypomagnesemia, <1.6 mg/dL | 1 (2.6) | 6 (15.8) | 0.113 | |
| Hypocalcemia, <4.0 mg/dL | 1 (2.6) | 0 (0) | 0.873 | |
Data are presented by mean ± SD for parametric data and median (IQR) for non-parametric data. Discrete outcomes were expressed as number of events and percentage. CRBSI, catheter-related blood stream infection; ICU, intensive care unit.
*
Bleeding was defined as an active bleeding in anywhere which requiring blood transfusion.