Comparison 2. Vitamin K antagonists versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Symptomatic VTE (DVT and PE)	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 1.94]
1.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 1.94]
2 Symptomatic DVT (proximal or distal)	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.13 [0.01, 2.62]
2.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.13 [0.01, 2.62]
3 Symptomatic PE	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.84]
3.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.84]
4 Total VTE (symptomatic and asymptomatic)	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 0.81]
4.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 0.81]
5 All‐cause mortality	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Adverse events	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Bleeding ‐ major	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	2.89 [0.12, 71.31]
7.1 Hip replacement	1	360	Odds Ratio (M‐H, Fixed, 95% CI)	2.89 [0.12, 71.31]