Comparison 3. DOAC versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Symptomatic VTE (DVT and PE)	1	2419	Odds Ratio (M‐H, Fixed, 95% CI)	0.20 [0.06, 0.68]
1.1 Hip replacement	1	2419	Odds Ratio (M‐H, Fixed, 95% CI)	0.20 [0.06, 0.68]
2 Symptomatic DVT (proximal or distal)	2	2459	Odds Ratio (M‐H, Fixed, 95% CI)	0.18 [0.04, 0.81]
2.1 Hip replacement	2	2459	Odds Ratio (M‐H, Fixed, 95% CI)	0.18 [0.04, 0.81]
3 Symptomatic PE	1	1733	Odds Ratio (M‐H, Fixed, 95% CI)	0.25 [0.03, 2.25]
3.1 Hip replacement	1	1733	Odds Ratio (M‐H, Fixed, 95% CI)	0.25 [0.03, 2.25]
4 Total VTE (symptomatic and asymptomatic)	1	1733	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.11, 0.33]
4.1 Hip replacement	1	1733	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.11, 0.33]
5 All‐cause mortality	1	1733	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.07, 1.66]
5.1 Hip replacement	1	1733	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.07, 1.66]
6 Adverse events	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	0.87 [0.74, 1.03]
6.1 Hip replacement	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	0.87 [0.74, 1.03]
7 Bleeding ‐ major	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.06, 16.02]
7.1 Hip replacement	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.06, 16.02]
8 Bleeding‐ clinically relevant non‐major	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.22 [0.76, 1.95]
8.1 Hip replacement	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.22 [0.76, 1.95]
9 Bleeding ‐ minor	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.18 [0.74, 1.88]
9.1 Hip replacement	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.18 [0.74, 1.88]
10 Reoperation	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10.1 Hip replacement	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
11 Wound infection	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.34 [0.46, 3.86]
11.1 Hip replacement	1	2457	Odds Ratio (M‐H, Fixed, 95% CI)	1.34 [0.46, 3.86]