Comparison 4. Anticoagulant (chosen at investigators' discretion) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Symptomatic VTE (DVT and PE)	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.50 [0.09, 2.74]
1.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.50 [0.09, 2.74]
2 Symptomatic DVT (proximal or distal)	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.03, 3.21]
2.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.03, 3.21]
3 Symptomatic PE	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.06, 16.13]
3.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.06, 16.13]
4 Total VTE (symptomatic and asymptomatic)	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.14, 0.50]
4.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.14, 0.50]
5 Asymptomatic DVT	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.13, 0.54]
5.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.13, 0.54]
6 Asymptomatic distal DVT	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.13, 0.54]
6.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.13, 0.54]
7 All‐cause mortality	1	842	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
7.1 Knee replacement	1	842	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Bleeding ‐ major	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	5.05 [0.24, 105.76]
8.1 Knee replacement	1	557	Odds Ratio (M‐H, Fixed, 95% CI)	5.05 [0.24, 105.76]