TABLE 1.
Demographic characteristics of the study subjects: opioid-exposed NOWS newborns that need treatment (+Opioids/+NOWS), mothers with prenatally opioid-exposed infants that did not require treatment for NOWS (+Opioids/-NOWS), and unexposed mothers with normal controls (-Opioids/-NOWS).
| Number of subjects | Maternal age in years- Mean (SD) | Gestational age at delivery in weeks– Mean (SD) | Alcohol history | Tobacco history | Birth weight (g) –Mean (SD) | NICU admission | NOWS development | ||
|---|---|---|---|---|---|---|---|---|---|
| (+Opioids/+NOWS) versus (+Opioids/-NOWS) | Cases | 32 | 31 (4.7) | 37.94 (3.16) | 4 (12%) | 30 (93%) | 2800 (780.7) | 32 (100%) | 32 (100%) |
| Controls | 32 | 28 (4.9) | 37.49 (2.96) | 3 (9%) | 31 (96%) | 2752 (671.2) | 11 (34%) | 0 | |
| q-value (FDR) | NA | 0.9947 | 0.9947 | 0.9947 | 0.9947 | 0.9947 | <0.00001 | <0.00001 | |
| +Opioids/+NOWS plus +Opioids/-NOWS versus -Opioids/-NOWS | Cases | 64 | 29.5 (5.1) | 37.72 (3.07) | 7 (11%) | 61 (95%) | 2776 (729.7) | 43 (67%) | 32 (50%) |
| Controls | 32 | 32.5 (4.1) | 38.09 (3.37) | 3 (9%) | 11 (34%) | 3117 (760.6) | 3 (9%) | 0 | |
| q-value (FDR) | NA | 0.8514 | 0.0053 | 0.0237 | 0.0643 | 0.0168 | 0.0052 | 0.0948 | |
| +Opioids/+NOWS versus -Opioids/-NOWS | Cases | 32 | 31 (4.7) | 37.94 (3.16) | 4 (12%) | 30 (93%) | 2800 (780.7) | 32 (100%) | 32 (100%) |
| Controls | 32 | 32.5 (4.02) | 38.09 (3.37) | 3 (9%) | 11 (34%) | 3117 (760.6) | 3 (9%) | 0 | |
| q-value (FDR) | NA | 0.5747 | 0.821 | 0.2522 | 0.024 | 0.1243 | <0.00001 | <0.00001 |