TABLE 2.
The analysis of +Opioids/+NOWS versus + Opioids/-NOWS. Significantly differentially methylated microRNAs based on FDR adjusted-p values < 0.05 provided with (AUC) ≥0.75 for NOWS detection. Details of corresponding CpG loci, chromosomes, and methylation status.
| TargetID | miR | CHR | p-Val | FDR p-Val | % Methylation | CI | Methylation | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Control | Difference | AUC | lower | upper | ||||||
| cg11210410 | miR-1268A | 9 | 3.12539E-38 | 2.70346E-32 | 74.62 | 64.79 | 9.83 | 0.82 | 0.72 | 0.93 | Hyper |
| cg14929554 | miR-5095 | 16 | 2.56839E-14 | 2.22166E-08 | 60.20 | 70.37 | −10.17 | 0.76 | 0.65 | 0.88 | Hypo |
| cg16769912 | miR-558 | 2 | 1.85302E-13 | 1.60286E-07 | 60.52 | 70.36 | −9.83 | 0.78 | 0.67 | 0.90 | Hypo |
| cg13790797 | miR-548G | 3 | 4.61626E-11 | 3.99307E-05 | 49.01 | 58.67 | −9.66 | 0.76 | 0.64 | 0.88 | Hypo |
| cg04312413 | miR-548F1 | 1 | 6.42158E-11 | 5.55466E-05 | 71.41 | 78.91 | −7.50 | 0.77 | 0.66 | 0.89 | Hypo |
| cg02656609 | miR-301A | 17 | 1.18711E-10 | 0.000102685 | 76.05 | 82.73 | −6.68 | 0.81 | 0.70 | 0.92 | Hypo |
| cg10046367 | miR-548W | 17 | 1.30176E-10 | 0.000112602 | 69.25 | 76.95 | −7.70 | 0.83 | 0.73 | 0.93 | Hypo |
| cg26481500 | miR-1278 | 1 | 1.48897E-10 | 0.000128796 | 77.09 | 83.57 | −6.48 | 0.78 | 0.67 | 0.89 | Hypo |
| cg23632539 | miR-5096 | 1 | 6.57986E-10 | 0.000569158 | 78.51 | 71.87 | 6.64 | 0.74 | 0.61 | 0.86 | Hyper |
| cg15350946 | miR-1273H | 4 | 6.59135E-10 | 0.000570152 | 45.23 | 54.40 | −9.18 | 0.73 | 0.61 | 0.85 | Hypo |
| cg06769231 | miR-2117 | 17 | 6.72269E-10 | 0.000581513 | 64.17 | 72.20 | −8.03 | 0.76 | 0.64 | 0.87 | Hypo |
| cg22395021 | miR-548H3 | 6 | 7.95169E-10 | 0.000687821 | 61.28 | 69.57 | −8.29 | 0.70 | 0.57 | 0.83 | Hypo |
| cg00071872 | miR-548AE2 | 16 | 9.20749E-10 | 0.000796448 | 14.56 | 9.27 | 5.29 | 0.72 | 0.60 | 0.85 | Hyper |
| cg18363417 | miR-573 | 4 | 2.94005E-09 | 0.00254314 | 73.90 | 80.45 | −6.54 | 0.77 | 0.65 | 0.88 | Hypo |
| cg21254731 | miR-939 | 8 | 3.15349E-09 | 0.002727773 | 81.93 | 87.17 | −5.24 | 0.86 | 0.77 | 0.95 | Hypo |
| cg02790122 | miR-1296 | 10 | 4.68281E-09 | 0.00405063 | 77.11 | 83.10 | −5.99 | 0.71 | 0.58 | 0.84 | Hypo |
| cg26042267 | miR-3663HG | 10 | 5.19928E-09 | 0.004497379 | 35.81 | 28.35 | 7.47 | 0.72 | 0.59 | 0.84 | Hyper |
| cg25249290 | miR-181A1HG | 1 | 8.31433E-09 | 0.007191897 | 61.56 | 69.35 | −7.79 | 0.73 | 0.61 | 0.86 | Hypo |
| cg19350059 | miR-548F5 | 13 | 8.80098E-09 | 0.007612844 | 18.63 | 13.02 | 5.61 | 0.74 | 0.62 | 0.87 | Hyper |
| cg00224335 | miR-4327 | 21 | 1.13961E-08 | 0.009857667 | 52.54 | 44.68 | 7.86 | 0.75 | 0.63 | 0.87 | Hyper |
| cg17777998 | miR-1183 | 7 | 1.58092E-08 | 0.013674961 | 38.38 | 46.76 | −8.38 | 0.71 | 0.59 | 0.84 | Hypo |
| cg13641189 | miR-658 | 22 | 2.75754E-08 | 0.02385271 | 11.27 | 6.90 | 4.37 | 0.79 | 0.68 | 0.91 | Hyper |
| cg03425468 | miR-92B | 1 | 3.25876E-08 | 0.028188258 | 11.44 | 7.06 | 4.38 | 0.75 | 0.63 | 0.87 | Hyper |
| cg24289256 | miR-548F3 | 1 | 4.69893E-08 | 0.040645767 | 72.95 | 79.16 | −6.21 | 0.70 | 0.58 | 0.83 | Hypo |
| cg03135982 | miR-3650 | 5 | 4.94006E-08 | 0.042731525 | 76.26 | 82.01 | −5.75 | 0.74 | 0.62 | 0.87 | Hypo |