TABLE 4.
Analysis of (+Opioids/+NOWS), versus (-Opioids/-NOWS, control). Details of CpG targets significantly differentially methylated microRNAs in NOWS. Differentially methylated CpG sites with Target ID, Gene ID, chromosome location, p-value, FDR p-value, and % methylation change details are given.
| CpG target | miR | CHR | p-value | FDR p-Val | % Methylation | AUC | CI | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Control | diffreence | lower | upper | Methylation | ||||||
| cg20276377 | miR-548G | 3 | 1.98166E-23 | 1.71414E-17 | 15.95839 | 25.9444 | −9.98601 | 0.65 | 0.53 | 0.77 | Hypo |
| cg01514668 | miR-129-2 | 11 | 8.5878E-13 | 7.42844E-07 | 12.95384 | 19.57678 | −6.62294 | 0.58 | 0.46 | 0.70 | Hypo |
| cg18576861 | miR-3621 | 9 | 4.85176E-11 | 4.19677E-05 | 23.36382 | 30.90311 | −7.53929 | 0.74 | 0.63 | 0.86 | Hypo |
| cg20351875 | miR-548C | 12 | 1.0169E-10 | 8.79621E-05 | 16.31689 | 22.83412 | −6.51723 | 0.67 | 0.55 | 0.79 | Hypo |
| cg25147193 | miR-181C | 19 | 1.44145E-10 | 0.000124685 | 8.817696 | 13.97549 | −5.157794 | 0.64 | 0.52 | 0.76 | Hypo |
| cg11479035 | miR-1276 | 15 | 2.1566E-10 | 0.000186546 | 84.82172 | 79.64312 | 5.1786 | 0.77 | 0.66 | 0.87 | Hyper |
| cg06871184 | miR-1238 | 19 | 4.3656E-10 | 0.000377624 | 64.27575 | 57.02732 | 7.24843 | 0.72 | 0.60 | 0.83 | Hyper |
| cg13781167 | miR-8081 | 9 | 1.58717E-09 | 0.001372905 | 64.99973 | 71.75161 | −6.75188 | 0.70 | 0.58 | 0.81 | Hypo |
| cg19756622 | miR-518A1 | 19 | 3.09143E-09 | 0.002674085 | 80.68514 | 75.23586 | 5.44928 | 0.82 | 0.72 | 0.92 | Hyper |
| cg17540499 | miR-592 | 7 | 3.8092E-09 | 0.00329496 | 31.95645 | 39.38867 | −7.43222 | 0.59 | 0.47 | 0.71 | Hypo |
| cg13767940 | miR-34B | 11 | 1.06906E-08 | 0.009247326 | 11.87235 | 16.98866 | −5.11631 | 0.64 | 0.52 | 0.76 | Hypo |
| cg26438516 | miR-1256 | 10 | 2.79234E-08 | 0.024153783 | 66.7636 | 60.35334 | 6.41026 | 0.71 | 0.60 | 0.83 | Hyper |