Table 4.
Temperature and weight of P. berghei-infected mice treated with ethanolic extract of the stem bark of T. macroptera in the suppressive and curative test.
| Suppressive test | Curative test | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | Temperature (°C) | Weight (g) | Temperature (°C) | Weight (g) | ||||||||
| Day 0 | Day 3 | %Change | Day 0 | Day 3 | %Change | Day 3 | Day 7 | %Change | Day 3 | Day 7 | %Change | |
| 1% DMSO | 34.47 ± 1.414 | 34.08 ± 1.540 | −1.14 | 28.67 ± 2.42b | 26.67 ± 3.01 | −7.23 | 34.22 ± 1.54 | 34.08 ± 1.003 | −0.41 | 25.56 ± 6.044 | 23.56 ± 5.74 | −8.14 |
| CQ5 mg/kg | 34.72 ± 1.150 | 34.78 ± 1.270 | 0.17 | 24.00 ± 2.09a | 26.83 ± 3.54 | 11.14 | 34.16 ± 1.61 | 34.42 ± 0.966 | 0.76 | 22.44 ± 4.55 | 24.44 ± 4.24 | 8.53 |
| 125 mg/kg | 35.18 ± 0.4262 | 34.88 ± 0.902 | −0.86 | 27.83 ± 3.76b | 30.00 ± 3.24 | 7.50 | 34.21 ± 1.58 | 34.47 ± 1.159 | 0.76 | 21.67 ± 5.72 | 24.44 ± 4.24 | 12.01 |
| 250 mg/kg | 34.05 ± 1.528 | 34.53 ± 1.398 | 1.39 | 27.33 ± 3.20a | 28.33 ± 3.50 | 3.59 | 33.82 ± 1.20 | 34.66 ± 1.000 | 2.45 | 23.00 ± 3.80 | 24.67 ± 5.45 | 7.01 |
| 500 mg/kg | 35.33 ± 1.011 | 34.95 ± 1.150 | −1.08 | 26.83 ± 3.25a | 27.67 ± 3.01 | 3.08 | 35.17 ± 1.56 | 34.94 ± 0.69 | −0.66 | 22.00 ± 4.41 | 22.67 ± 3.31 | 2.99 |
| Water | 34.23 ± 1.500 | 34.70 ± 1.092 | 1.36 | 22.67 ± 2.33a | 24.83 ± 2.317 | 9.09 | 34.18 ± 1.57 | 34.31 ± 1.188 | 0.38 | 22.22 ± 4.38 | 23.00 ± 5.38 | 3.45 |
Values are given as mean ± SD. a,bValues carrying the same superscript letter are not significantly different at p < 0.05.