TABLE 1.
Included studies
| Study | Country | Design | N° of pts. (case–control) | F‐up (months) | Control therapy | Cause of injury | Outcomes evaluated |
|---|---|---|---|---|---|---|---|
| Kim et al., 2020 10 | USA | Retrospective comparative | 116 (42–74) | 1 | NPWT |
NPWTi‐d: 17 Ischemic, 16 Neuropathic, 16 Decubitus, 17 Surgical, 3 VI, 4 Trauma, 3 Other NPWT: 6 Ischemic, 14 Neuropathic, 4 Decubitus, 13 Surgical, 2 VI, 1 Trauma, 1 Other |
N° of operations, length of hospital stay, time to final procedure, wound closure/coverage, wounds closed at one month. |
| Chowdhry et al., 2019 11 | USA | Retrospective comparative | 30 (15–15) | 3 | Wet to moist dressing | NPWTi‐d/ NPWT: 15 sternal wounds after sternotomy | Therapy / dressing days, debridement/dressing changes, time to 1° closure |
|
Cole et al., 2020 12 |
USA |
Retrospective Comparative |
10 (5–5) |
NA | Advanced wound dressing |
NPWTid: 1 Trauma, 1 VLU, 2 PU, 1 DFU NPWT: 3 DFU, 1 VLU, 1 Trauma |
Number of debridements and wound complications, final outcome |
| Gabriel et al., 2014 13 | USA | Retrospective comparative | 82 (48–34) | 6 | NPWT |
NPWTid: 13 UE, 14 LE, 21 Trunk NPWT: 11 UE, 4 LE, 19 Trunk |
Length of hospital stay, time to wound closure, N° of surgical debridement in the OR, LOT |
| Schreiner et al., 2020 14 | Germany | Retrospective comparative | 27 (11–16) | NA | NPWT | NPWTi‐d/NPWT: 27 SJI | Length of hospital stay, N° NPWT, N° sponge dressing changes, time to wound closure, chest wall resection, muscle flap transposition, complications, bacterial status |
| Kim et al., 2020 15 | USA | RCT | 181 (93–88) | NA | NPWT |
NPWTi‐d: Ulcers: 2 Arterial, 39 Diabetic, 2 Radiation, 19 Pressure, 2 Venous. 1 Fasciitis, 1 Other, 3 Surgical dehisced, 10 Surgical non‐dehisced, 3 Trauma, 1 Burn NPWT: Ulcers: 3 Arterial, 39 Diabetic, 12 Pressure, 1 Radiation, 3 Venous. 1 Other, 10 Surgical dehisced, 14 Surgical non‐dehisced, 5 Trauma |
N° of inpatient OR debridements, bacterial status, high versus low bacteria count at first dressing change in pts. with initial high bacteria, closed wounds and time to closure/coverage in pts. with high versus low bacteria count, type of wound closure |
| Omar et al., 2016 16 | Germany | Prospective comparative | 20 (10–10) | 4 | NPWT | NPWTi‐d/NPWT: 10 acute wounds LE (traumatic/infected) | Surgeries, time to wound closure, length of hospital stay, wound size |
| Goss et al., 2014 17 | USA, Italy | Prospective Comparative | 13 (7–7) * | 7 days | NPWT |
NPWTi‐d: 1 AI, 1 Trauma, 1 NF, 1 Ischemic, 8 CVU, 4 DFU NPWT: NA |
Bioburden reduction at post‐op. day 7, maintenance of bioburden reduction after debridement to closure. |
| Kim et al., 2014 18 | USA | RCT | 142 (34–74) | 1 | NPWT |
NPWTi‐d 6 min: 7 Ischemic, 6 Neuropathic, 6 Decubitus, 9 Surgical, 2 VI, 2 Trauma, 2 Other NPWT: 17 Ischemic, 16 Neuropathic, 16 Decubitus, 17 Surgical, 3 Venous, 4 Traumatic, 3 Other |
N°. of OR visits, length of hospital stay, time to final surgical procedure, closing rate, remained closed at 1 mo, culture improvement, culture improvement without Gram‐, corynebacterium, and yeast. |
| Kim et al., 2014 18 | USA | RCT | 142 (34–74) | 1 | NPWT | NPWT‐id 20 min: 8 Ischemic, 7 Neuropathic, 4 Decubitus, 10 Surgical, 1 VI, 1 Trauma, 3 Other | ‐“‐ |
| Gabriel et al., 2008 19 | USA | Prospective comparative | 30 (15–15) | 6 | NPWT |
NPWTi‐d: 3 NF, 2 PU, 3 Expos. Hardware, 2 SW, 5 Trauma NPWT: 5 DU, 4 NF, 6 Expos. Hardware |
Days treated, infection cleared, day wound cleared of infection, wound closed, wound closure method (%), 1°/secondary intention, skin graft, local flap, time to wound closure, time to discharge. |
| Timmers et al., 2008 20 | Netherlands | Retrospective comparative | 124 (30–94) | 43–89 | NPWT | NPWTi‐d: 33 Osteomyelitis, 13 Soft tissue, 12 Trauma, 3 NF, 1 Pilonidal sinus | N° of hospital admissions, N° operations, N° of operations per admission, duration of hospital stay, recurrence of osteomyelitis |
| Burusapat et al., 2021 21 | Thailand | Prospective Comparative | 48 (24–24) | NA | NPWT |
NPWTi‐d: 12 PU, 4 DU, 2 Tumour surgery, 4 NF, 2 Trauma NPWT: 12 PU, 3 DU, 2 Tumour surgery, 4 NF, 3 Trauma |
Wound depth and % of reduction, wound volume and % of reduction, pathogens |
| Giri et al., 2020 22 | India | RCT | 48 (25–23) | 10 days | NPWT | NPWTi‐d/NPWT: DFU, Trauma, Insect/snake bite | Change in histological parameters between day 1/10, comparison of CFU and % of reduction in wound size at day 1/ 10. |