Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 19;20(7):1037–1047. doi: 10.1038/s41592-023-01903-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 2 — a, Assuming a cell population with an actual interaction frequency of 75%, nuclear cryosections intersecting both loci can be obtained from nuclei in both interacting and non-interacting states. b, For any pair of loci, a GAM cryosection might detect either both loci, one locus, or neither. Co-segregation frequency or normalized linkage (D’) can be applied to infer proximity of the two loci. c, SLICE provides a statistical model to identify pairs of loci interacting above the background at their genomic distance, and to estimate the proportion of cells in the population with pairs in the interacting state (Probability of interaction or Pi).