Table 5.

Summary of studies comparing AAION and NAAION.

First author (ref)	Year	Design	Patients (n)		Significantly different variables between AAION compared to NAAION
			NAAION	AAION	Clinical	Biological	Ophthalmo.	Imaging	Main results
Costello [10]	2004	Retrospective	287	121	–	+	–	–	↑ESR ↑ CRP ↑ Platelet count
Inanc [8]	2017	Retrospective	33	12	–	+	–	–	↑Neutrophil/lymphocyte
Koçak [7]	2020	Retrospective	41	16	–	+	–	–	↑Age ↑ESR ↑ Neutrophil/lymphocyte ↑Monocyte/high-density lipoprotein
Siatkowski [16]	1992	Retrospective	19	16	–	+	+	–	↑Age ↑ESR ↑ Cup/disc ↓Choroidal filling times ↑Disk pallor frequency
Monteiro [12]	2006	Prospective	24	13	–	–	+	–	↑Optic disc area
Danesh-Meyer [29]	2001	Retrospective	32	42	–	–	+	–	↑Cupping frequency
Danesh-Meyer [13]	2010	Retrospective	53	18	+	–	+	–	↑Age ↑Visual acuity ↑Cup/disc ↓MD ↓ NFL thickness
Jonas [11]	1988	Retrospective	33	7	–	–	+	–	↑Optic disc area
Huna-Baron [19]	2006	Retrospective	16	16	–	–	+	–	↓Intraocular pressure
Valmaggia [17]	1999	Prospective	17	5	–	–	+	–	↓Choroidal filling times
Jonas [18]	2008	Retrospective	10	6	–	–	+	–	↓CRA collapse pressure
Pellegrini [15]	2019	Retrospective	20	20	+	–	+	–	↑Age ↑Visual acuity ↓MD ↓ Peripapillary CVI
Ghanchi [20]	1996	Retrospective	4	7	–	–	–	+	↓Blood flow in the posterior ciliary arteries
Remond [21]	2017	Prospective	15	15	–	–	–	+	↑Central Bright Spot Sign frequency

Ophthalmo ophthalmological, ESR erythrocyte sedimentation rate, CRP C-reactive protein, MD visual field mean deviation, NFL nerve fibre layer, CRA central retinal artery, CVI choroidal vascularity index