Table 1.

Summary of patient characteristics.

Patient characteristics
Median visual acuity at diagnosis, logMAR (range, IQR)	OD		OS
	0.0 (−0.1 to 0.5, 0–0.2)		0.02 (−0.1 to 0.32, −0.02 to 0.2)
Median 10-2 Humphrey visual field deficit at diagnosis, dB (range, IQR)	−3.73 (−29.96 to −1.81, −8.52 to −3.21)		−2.77 (−24.48 to −0.30, −7.55 to −2.05)
Disease distribution	Parafoveal	Pericentral		Mixed
	18	2		3
Median daily dose, mg (range, IQR)	200 (57–400, 200–400)
Median duration of use, years (range, IQR)	19 (4–50, 14.5–23)
ELM disruption on OCT imaging at diagnosis	15 (63%)
Comparison of symptomatic and asymptomatic patients
	Symptomatic		Asymptomatic
Number	9 (39%)		14 (61%)
Mean age, years (range, SD)	55.9 (30–82, 15.8)		57.8 (28-86, 17.4)
Median duration of use, years (range, IQR)	15 (4–25, 13-21)		20 (7-50, 15.25–24.25)
Median daily dose, mg (range, IQR)	238.4 (57.1–400, 200–400		277.6 (200–400, 200–400)
Median visual acuity of worst seeing eye, logMAR (range, IQR)	0.02 (-0.1 to 0.5, 0 –0.2)		0 (−0.1 to 0.3, 0–0.19)
Median field deficit of worst seeing eye at diagnosis, dB (range, IQR)	−7.26 (-29.96 to −3.15, −15.85 to −4.03)		-3.51 (-24.48 to −1.81, −6.09 to −2.81)
Disease distribution
Parafoveal	5		8
Pericentral	1		2
Mixed	2		0
ELM disruption on OCT imaging at diagnosis	7 (78%)		7 (50%)
Comparison of patients based on ELM status on OCT at diagnosis
	ELM disruption at diagnosis		ELM preserved at diagnosis
Number	15		9
Mean age in years (range, SD)	55 (28–86, 46.5–72)		55 (30–71, 36–62)
Median visual acuity of worst seeing eye, logMAR (range, IQR)	0.14 (0.5 to −0.1, 0.02–0.3))		0.0 (0.2 to −0.1, −0.1 to 0)
Median field deficit of worst seeing eye at diagnosis, dB (range, IQR)	-13.55 (−29.96 to −1.81, −22.90 to −4.88)		−3.51(−12.82 to −2.22, −4.28 to −3.11)
Median duration of use, years (range, IQR)	15.5 (10–5, 15–20.1)		20(4–40, 8–25)
Median daily dose, mg (range, IQR)	200 (57.1–400, 200–400)		200 (200–400, 200–400)

IQR interquartile range, dB decibels, SD standard deviation.