Table 3.
Multivariable Cox Hazard Proportion Analysis for the overall incidence of glaucoma by modeling.
| Variables | Model 1 | Model 2 | Model 3 | Model 4 | ||||
|---|---|---|---|---|---|---|---|---|
| Adjusted HR (95% CI) | P value | Adjusted HR (95% CI) | P value | Adjusted HR (95% CI) | P value | Adjusted HR (95% CI) | P value | |
| Group | ||||||||
| Control | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| Case | 1.4 (1.24–1.59) | <0.001 | 1.3 (1.15–1.48) | <0.001 | 1.32 (1.16–1.5) | <0.001 | 1.31 (1.15–1.48) | <0.001 |
| Hypertension | ||||||||
| No | 1.00 | 1.00 | ||||||
| Yes | 1.08 (0.97–1.22) | 0.168 | 1.09 (0.97–1.22) | 0.167 | ||||
| Diabetes mellitus | ||||||||
| No | 1.00 | 1.00 | 1.00 | |||||
| Yes | 1.3 (1.15–1.48) | <0.001 | 1.33 (1.18–1.5) | <0.001 | 1.3 (1.15–1.47) | <0.001 | ||
| Hyperlipidaemia | ||||||||
| No | 1.00 | 1.00 | 1.00 | |||||
| Yes | 1.11 (0.97–1.26) | 0.136 | 1.13 (1–1.29) | 0.059 | 1.1 (0.97–1.26) | 0.144 | ||
| Chronic renal failure | ||||||||
| No | 1.00 | 1.00 | 1.00 | |||||
| Yes | 1.99 (1.36–2.9) | <0.001 | 2.02 (1.38–2.95) | <0.001 | 1.97 (1.35–2.89) | <0.001 | ||
| Age group (year) | ||||||||
| <50 | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| 50–59 | 3 (2.47–3.65) | <0.001 | 2.78 (2.28–3.39) | <0.001 | 2.81 (2.3–3.42) | <0.001 | 2.78 (2.28–3.39) | <0.001 |
| 60–69 | 4.54 (3.8–5.42) | <0.001 | 4.05 (3.37–4.86) | <0.001 | 4.13 (3.45–4.95) | <0.001 | 4.05 (3.37–4.86) | <0.001 |
| 70–79 | 5.33 (4.44–6.4) | <0.001 | 4.66 (3.85–5.63) | <0.001 | 4.79 (3.97–5.77) | <0.001 | 4.63 (3.83–5.61) | <0.001 |
| ≥80 | 3.22 (2.5–4.16) | <0.001 | 2.91 (2.25–3.77) | <0.001 | 3 (2.32–3.87) | <0.001 | 2.91 (2.25–3.78) | <0.001 |
| Sex | ||||||||
| Male | 1.00 | 1.00 | ||||||
| Female | 0.96 (0.87–1.05) | 0.364 | 0.96 (0.87–1.06) | 0.405 | ||||
| Residence | ||||||||
| Seoul (metropolitan) | 1.00 | 1.00 | 1.00 | |||||
| 2nd area | 0.84 (0.66–1.05) | 0.13 | 0.84 (0.66–1.05) | 0.13 | 0.84 (0.67–1.06) | 0.145 | ||
| 3rd area | 0.84 (0.68–1.05) | 0.126 | 0.84 (0.68–1.05) | 0.121 | 0.85 (0.68–1.05) | 0.136 | ||
| 4th area | 0.81 (0.72–0.92) | <0.001 | 0.81 (0.72–0.91) | <0.001 | 0.82 (0.73–0.92) | <0.001 | ||
| Household income | ||||||||
| 0–30% | 1.00 | |||||||
| 30–70% | 0.96 (0.83–1.1) | 0.569 | ||||||
| 70–100% | 1.05 (0.92–1.2) | 0.445 | ||||||
| Model criterion value | AUC: 0.649; AIC: 33288.08 | AUC: 0.664; AIC: 33236.13 | AUC: 0.663; AIC: 33236.03 | AUC: 0.665; AIC: 33238.82 | ||||
AUC Area Under the Curve, AIC Akaike’s Information Criterion, the model with the largest AUC or lowest AIC value being considered the best.