Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 10;13:11180. doi: 10.1038/s41598-023-38084-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Biogenesis and local and distant migration of MVSs (A–D) Biogenesis of MVS. (A) Spheresomes (sp) aggregate in a specific region of the cell membrane. Cell membrane begins to evaginate pushed by spheresomes. (B) A membrane evagination originates the multivesicular sphere (mvs), fulfilled by spheresomes. (C) The cell releases the MVS by narrowing the cell membrane (arrow). MVSs frequently appear along cytoplasmatic prolongations. (D) MVSs are released into the extracellular medium. (E–G) Short distance migration of MVSs and spheresomes. (E) Comparison of exosomes-loaded multivesicular bodies (mvb) and early MVS. Differences in the size of both multivesicular structure and inside vesicles are shown. (F) Panoramic view of MVSs surrounding a tumoural astrocyte. (G) Rupture of MVS membrane releases spheresomes (H–I). Long distance migration of MVSs and spheresomes. (H) Small blood vessel (bv) and nearby myelin-ensheathed axons (ax). An erythrocyte (er) and a leukocyte (le) are observed in the lumen of the vessel. (I) Detail from (H) showing an MVS with a dilated membrane in the lumen of a vessel. A small extension of the endothelial cell seems to guide the MVS.