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. 2022 Oct 17;37(10):2061–2068. doi: 10.1038/s41433-022-02286-x

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© The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 3 — Fold change (FC) values >2 or <0.5 and a p value <0.05 were set as the filter criteria (A). The vertical dotted line at 0 at the X-axis delimits up- and downregulation. The red and green plots represent significant upregulated and downregulated genes with >2.0-fold change and p value <0.05 in PDR patients (B). Comprehensive interaction networks of the proteins with altered expression based on STRING tools (C). Bioinformatics analysis of the differentially expressed exosome proteins. D Gene Ontology (GO) enrichment analysis of differential proteins. Top 10 items are listed in biological process, cell component and molecular function, respectively based on their statistical significance. E KEGG pathway enrichment analysis of differential proteins. Top 10 items are listed on their statistical significance.