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. 2023 Jul 10;14:4091. doi: 10.1038/s41467-023-39744-3

Fig. 5. Bone regeneration properties of CFO@BTO/P(VDF-TrFE) membranes in vivo under co-morbidity conditions.

Fig. 5

a, b Schematic illustration of CSCM repairing skull defects under co-morbidity conditions, including the osteogenic inhibition model (a) and the systemic inflammatory model (b). c The process of Dexamethasone (Dex) injection for osteogenic suppression and application of magnetic field for CSCM reactivation. Micro-CT images and H&E staining of tissue sections after dexamethasone injection to inhibit osteogenesis, with and without magnetic treatment (4 weeks). NB new bone. n = 3 rats for per group; mean ± SEM. *P < 0.05, one-way ANOVA. d The schematic diagram of the systemic inflammation rat model and application of magnetic field for CSCM reactivation. Micro CT images and H&E staining of tissue sections after LPS injection for systemic inflammation, with and without magnetic treatment (4 weeks). n = 3 rats for per group; mean ± SEM. *P < 0.05, one-way ANOVA. Source data are provided as a Source Data file. The schematic diagrams were created with BioRender.com.