Table 2.

Pathway enrichment analysis for the 387 replicated metabolites associated with total fat (%).

Metabolite set	Hits	Expected	Total	P-value
Aminoacyl-tRNA biosynthesis	15	2.91	48	3.84E−08
Valine, leucine and isoleucine biosynthesis	6	0.49	8	1.08E−06
Arginine biosynthesis	7	0.85	14	5.86E−06
Glycine, serine and threonine metabolism	10	2.00	33	1.21E−05
Alanine, aspartate and glutamate metabolism	9	1.70	28	2.01E−05
Cysteine and methionine metabolism	9	2.0013	33	8.69E−05
Pantothenate and CoA biosynthesis	6	1.15	19	6.05E−04
Phenylalanine, tyrosine and tryptophan biosynthesis	3	0.24	4	8.27E−04
Glycerophospholipid metabolism	8	2.18	36	1.00E−03
Sphingolipid metabolism	6	1.27	21	1.10E−03
D-Glutamine and D-glutamate metabolism	3	0.36	6	3.78E−03
Taurine and hypotaurine metabolism	3	0.49	8	9.68E−03
Nicotinate and nicotinamide metabolism	4	0.91	15	1.03E−02
Glyoxylate and dicarboxylate metabolism	6	1.94	32	1.06E−02
Histidine metabolism	4	0.97	16	1.31E−02
Phenylalanine metabolism	3	0.61	10	1.90E−02
Nitrogen metabolism	2	0.36	6	4.65E−02

Total, total number of metabolites in this metabolite set (pathway); expected, expected number of metabolites projected to each set; hits, observed number of metabolites of interest projected to each set.