Table 3.

Pathway enrichment analysis for the 120 replicated metabolites associated with fat distribution.

Metabolite set	Hits	Expected	Total	P-value
Aminoacyl-tRNA biosynthesis	7	0.96	48	2.61E−05
Valine, leucine and isoleucine biosynthesis	3	0.16	8	3.80E−04
Glycerophospholipid metabolism	5	0.72	36	5.58E−04
Histidine metabolism	3	0.32	16	3.40E−03
Sphingolipid metabolism	3	0.42	21	7.55E−03
Alanine, aspartate and glutamate metabolism	3	0.56	28	1.69E−02
Cysteine and methionine metabolism	3	0.66	33	2.63E−02
Arginine biosynthesis	2	0.28	14	3.03E−02
Nicotinate and nicotinamide metabolism	2	0.30	15	3.46E−02
Glycerolipid metabolism	2	0.32	16	3.90E−02
Valine, leucine and isoleucine degradation	3	0.80	40	4.34E−02

Total, total number of metabolites in this metabolite set (pathway); expected, expected number of metabolites projected to each set; hits, observed number of metabolites of interest projected to each set.