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. 2023 Jul 10;8:97. doi: 10.1038/s41541-023-00694-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Chemical structure of INI-2002. b SEAP activation in HEK293 cells expressing human TLR4 by indicated doses of INI-2002. Data were reported as fold changes in SEAP production over vehicle control. c–f Human PBMCs from five different donors were stimulated with indicated doses of INI-2002 for 24 h. Supernatants were then analyzed for indicated cytokine production using a custom U-PLEX MesoScale Discovery (MSD) assay for all cytokines shown.