Table 2.

Binding affinity of [¹⁹F]FNM to the NMDA PCP site

Rat brain membranes suspensions	IC50a ± SEM (M)	Kib ± SEM (M)
Frontal cortex	8.08 ± 1.51.10−5	3.39 ± 0.72.10−5
Hippocampus	5.29 ± 0.97.10−5	1.92 ± 0.14.10−5
Forebrain	1.30 ± 0.89.10−5	7.81 ± 5.36.10−6

a: IC₅₀ is the concentration of [¹⁹F]FNM inhibiting 50% of [³H]TCP binding; b: K_i was obtained by transforming IC₅₀ values according to the Cheng and Prusoff equation. For the transformation, K_D values of the [³H]TCP in hippocampus, frontal cortex and forebrain was obtained from the literature [31, 32]