Table 2.
SF-12 and SF-36 scores per study
| First Author, year of publication | Dantas [51] | Gu [44] | Guo [38] SF-12 |
Psaras [49] | Alcalar [54] | Nader [50]d | Psaras [49] | Vega-Beyhart [52] | Ye [53]d | Vega-Beyhart [19] 52 |
|---|---|---|---|---|---|---|---|---|---|---|
| Disease | AC | AC | AC | AC | CD | CD | CD | CD | CD | PRL |
| Baseline |
Mean N = 14a |
Median [IQR] N = 44 |
Mean ± SD N = 154 |
Mean ± SD N = 14 |
Mean ± SD N = 8 |
Uncleare N = 8 |
Mean ± SD N = 5 |
Median [IQR] N = 7 |
Unclearg N = 7 |
Median [IQR] N = 28 |
| Physical functioning | 54.09 = | 49.1 ± 9.3 = | 51.0 ± 25.8 | 18.63 ± 5.61c | 75 = f | 37.6 ± 32.4 | 45 [20–85]↓ | 55 [52–60] | 82 [48–95]↓ | |
| Role physical | 50.00↓ | 40.9 ± 11.4↓ | 43.2 ± 29.0 | 5.63 ± 1.99 | 75 =f | 25.0 ± 23.1 | 25 [0–50]↓ | 29 [23–32] | 50 [0–100]↓ | |
| Bodily pain | 43.64↓ | 36.7 ± 11.7↓ | 35.7 ± 20.6 | 6.81 ± 3.52c | 25 =f | 44.6 ± 24.2 | 45 [25–67]↓ | 58 [54–62] | 78 [45–90] = | |
| General health | 63.36 = | 32.0 ± 10.7 = | 39.9 ± 29.7b | 11.88 ± 3.68c | 38 =f | 39.7 ± 37.8b | 40 [20–45] = | 34 [30–39] | 48 [26–65]↓ | |
| Social functioning | 60.00 = | 38.3 ± 12.1↓ | 43.4 ± 34.7 | 7.00 ± 2.14 | 62 =f | 31.6 ± 32.9b | 50 [37–62]↓ | 50 [45–55] | 62 [40–75]↓ | |
| Role emotional | 45.27 = | 35.1 ± 12.8↓ | 39.7 ± 31.3b | 4.25 ± 1.28 | 62 =f | 26.0 ± 29.3b | 0 [0–0]↓ | 38 [32–41] | 50 [0–100] ↓ | |
| Mental health | 66.91 = | 37.2 ± 5.6↓ | 38.2 ± 37.2b | 20.00 ± 5.90 | 62 =f | 43.8 ± 42.7b | 44 [16–67]↓ | 56 [50–60] | 56 [36–68]↓ | |
| Vitality | 45.45↓ | 44.7 ± 10.6↓ | 33.8 ± 29.4b | 13.63 ± 5.15 | 50 =f | 47.2 ± 38.0 | 45 [10–60] = | 32 [28–35] | 45 [35–67]↓ | |
| MCS | 38.9 ± 8.0↓ | 29 [22–53]↓ | 57 [31–69]↓ | |||||||
| PCS | 39.6 ± 8.8↓ | 44 [16–70]↓ | 66 [36–81]↓ | |||||||
| Total | 65.4 [63.2–67.7] = | |||||||||
| First follow-up | 6 mos postop | Mean 2.35 mos postop, N = 6 h | ||||||||
| Physical functioning | 49 [42–52] | |||||||||
| Role physical | 23 [19–30] | |||||||||
| Bodily pain | 65 [60–70] | |||||||||
| General health | 28 [22–34] | |||||||||
| Social functioning | 53 [50–69] | |||||||||
| Role emotional | 45 [40–50] | |||||||||
| Mental health | 51 [45–59] | |||||||||
| Vitality | 25 [20–30] | |||||||||
| Total | 75.3 [70.1–82.3] = | |||||||||
| Second follow-up | Mean 7.4 mos postop, N = 4 h | |||||||||
| Physical functioning | 50 [45–54] | |||||||||
| Role physical | 30 [27–34] | |||||||||
| Bodily pain | 60 [66–64] | |||||||||
| General health | 42 [60–47] | |||||||||
| Social functioning | 61 [58–65] | |||||||||
| Role emotional | 58 [52–61] | |||||||||
| Mental health | 55 [50–60] | |||||||||
| Vitality | 39 [35–42] |
SF-12 and SF-36 scores for refractory patients with acromegaly, Cushing’s Disease and prolactinoma per study. AC acromegaly, CD Cushing’s Disease, IQR interquartile range, MCS mental component summary, mos months, PCS physical component summary, postop postoperative, PRL prolactinoma, SD standard deviation, ↓ significantly lower compared to patients in remission; ↑significantly higher compared to patients in remission, no P-value reported, = tested and no significant difference compared to patients in remission
aNumber of patients not reported in article. Author provided information upon request
bRefractory patients scored significantly lower than healthy controls
cRefractory patients scored significantly lower than healthy controls and patients in remission (no post-hoc analysis was performed)
dValues estimated based on figure, absolute values were not presented
eUnclear whether reported numbers concern mean or median values
fAll SF-36 domain scores were lower in refractory patients compared to patients in remission, however not significant
gUnclear what the values indicate. Figure does not include a legenda
hMissing data was not reported in article. Author provided information upon request