Fig. 4.

Testing the classifier on our in-house clinical samples. (a) The two-dimensional representation of the reference cohort samples (n = 399) using the t-SNE method based on DNA methylation profiles to which we added the samples from the clinical test cohort (n = 72). (b) Confusion matrices with no filters (upper panel) and with filters (lower panel) for the clinical test cohort. (c) A heatmap overview of the neural networks, support vector machine, and random forest results corroborated with clinical, pathological and molecular data.