Table 4.

Clinical manifestations according to the age group.

Variable	Age groups
	0–1 years old (n = 105)	2–5 years old (n = 276)	6–11 years old (n = 568)	12–16 years old (n = 422)	p-Value*
Clinical presentation
Symptomatic	6 (5.7%)	25 (9.1%)	55 (9.7%)	52 (12.3%)	0.174
Asymptomatic	99 (94.3%)	251 (90.9%)	513 (90.3%)	370 (87.7%)
General manifestations
Fever	65 (61.9%)	171 (62.0%)	305 (53.7%)	184 (43.6%)	<0.001
Headache**	4 (3.8%)	47 (17.0%)	231 (40.7%)	182 (43.1%)	<0.001
Anosmia	0 (0.0%)	0 (0.0%)	7 (1.2%)	27 (6.4%)	<0.001
Dysgeusia	0 (0.0%)	0 (0.0%)	5 (0.9%)	18 (4.3%)	<0.001
Myalgia	0 (0.0%)	5 (1.8%)	30 (5.3%)	29 (6.9%)	0.002
Arthralgia	0 (0.0%)	2 (0.7%)	9 (1.6%)	17 (4.0%)	0.004
Malaise	6 (5.7%)	19 (6.9%)	107 (18.9%)	104 (24.6%)	<0.001
Respiratory symptoms
Cough	62 (59.0%)	141 (51.1%)	293 (51.6%)	211 (50.0%)	0.425
Odynophagia	8 (7.6%)	63 (22.8%)	201 (35.4%)	184 (43.6%)	<0.001
Rhinorrhea	70 (66.7%)	144 (52.2%)	258 (45.4%)	183 (43.4%)
Gastrointestinal symptoms
Nausea	5 (4.8%)	4 (1.4%)	27 (4.8%)	18 (4.3)	0.120
Abdominal pain	0 (0.0%)	14 (5.1%)	48 (8.5%)	17 (4.0%)	0.001
Vomiting	12 (11.4%)	24 (8.7%)	41 (7.2%)	15 (3.6%)	0.006
Diarrhea	17 (16.2%)	13 (4.7%)	27 (4.8%)	15 (3.6%)	<0.001
Treatment
No treatment	6 (5.7%)	26 (9.4%)	55 (9.7%)	52 (12.3%)	0.496
Outpatient care/symptomatic treatment	98 (93.3%)	249 (90.2%)	510 (89.8%)	367 (87.6%)
Hospitalization	1 (1.0%)	1 (0.4%)	3 (0.5%)	3 (0.7%)
Reinfection
Positive reinfection	3 (2.9%)	1 (0.4%)	11 (1.9%)	6 (1.4%)	0.224

Data are presented as frequencies (percentages). Chi-square was performed for comparisons.

*Comparison between the initial and final measure; A p-value ≤0.05 was considered statistically significant.

**Irritability was considered in children under 5 years of age, and headache for 5 years and older.