Table 2.
Subgroup analysis of pooled HRs and 95% CIs in all-cause mortality, CVD mortality, stroke.
| Variable | No. of studies | No. of patients | Effects model | HR (95% CI) | P | Heterogeneity | P (begg) | P (egger) | |
|---|---|---|---|---|---|---|---|---|---|
| I2,% P | |||||||||
| All-cause mortality | |||||||||
| Total | 10 | Random | 1.15 (1.05,1.25) | 0.002 | 78.6 | 0.000 | 0.502 | 0.693 | |
| SEX | |||||||||
| Men | 7 | 10,32,792 | 1.21 (1.05,1.39) | 0.008 | 87.1 | 0.000 | |||
| Women | 7 | 859,992 | 1.04 (0.95,1.15) | 0.416 | 62.0 | 0.005 | |||
| Design | |||||||||
| RC | 8 | 802,980 | 1.10 (1.00, 1.21) | 0.059 | 59.3 | 0.031 | |||
| PC | 5 | 16,41,6,116 | 1.23 (1.06, 1.42) | 0.005 | 85.1 | 0.000 | |||
| CVD mortality | |||||||||
| Total | 12 | 13,28,036 | Random | 1.14 (0.96,1.35) | 0.127 | 60.7 | 0.003 | 0.304 | 0.826 |
| SEX | |||||||||
| Men | 8 | 5,89,737 | 1.14 (0.85, 1.54) | 0.388 | 67.8 | 0.003 | |||
| Women | 8 | 6,47,175 | 0.96 (0.83,1.12) | 0.622 | 0.0 | 0.489 | |||
| Design | |||||||||
| RC | 6 | 8,72,243 | 0.99 (0.81,1.22) | 0.951 | 57.5 | 0.028 | |||
| PC | 6 | 4,55,793 | 1.42 (1.11,1.82) | 0.005 | 42.9 | 0.136 | |||
| Stroke | |||||||||
| Total | 4 | 7,38,181 | Random | 1.14 (0.82,1.58) | 0.432 | 96.7 | 0.000 | 0.308 | 0.666 |
| SEX | |||||||||
| Men | 2 | 3,52,486 | 0.89 (0.80,1.00) | 0.057 | 0.0 | 0.815 | |||
| Women | 2 | 1,87,609 | 1.04 (0.87,1.24) | 0.691 | 0.0 | 0.535 | |||
| Design | |||||||||
| RC | 1 | 3,43,687 | 1.04 (0.83, 1.30) | 0.435 | 97.8 | 0.000 | |||
| PC | 3 | 3,94,494 | 1.17 (0.79, 1.74) | 0.727 | 96.7 | 0.000 | |||
CVD, cardiovascular disease; PC, prospective cohort; RC, retrospective cohort; HR, hazard ratio; CI, confidence interval.