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. 2023 Jun 27;14:1160783. doi: 10.3389/fmicb.2023.1160783

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Copyright © 2023 Sun, Zhang, Liu, Liu, Zhang, Fan, Zhang, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in the alpha diversity and beta diversity of the gut microbiota in IBS-D rats. (A) Venn diagram. (B) Shannon (alpha diversity index). (C) Principal coordinate analysis (PCoA) analysis of the gut microbiota at OTU level (beta diversity index). The data were represented as mean ± SEM. NC, control group; MC, model control group; CKF, Chang-Kang-Fang group; PFK, Bifico group; PFK-TM, Bifico target-colon capsule group; CKF-D + PFK, Chang-Kang-Fang combined with Bifico group; CKF-D + PFK-TM, Chang-Kang-Fang combined with Bifico target-colon capsule group.