Table 4.
Antipsychotic multivariate meta-regression results and adverse effects on sleep.
| Treatment | Insomnia | Somnolence | Sedation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CrI | P-value | OR | 95% CrI | P-value | OR | 95% CrI | P-value | |
| Amisulpride | 1.14 | 0.72, 1.81 | 0.565 | 5.47 | 0.89, 33.46 | 0.066 | 0.12 | 0.01, 2.19 | 0.151 |
| Aripiprazole | 1.17 | 0.90, 1.51 | 0.236 | 1.25 | 0.51, 3.08 | 0.632 | 6.69 | 0.34, 131.48 | 0.211 |
| Aripiprazole LAI | 0.92 | 0.57, 1.48 | 0.736 | 1.67 | 0.36, 7.89 | 0.514 | – | – | – |
| Asenapine | 0.66 | 0.38, 1.12 | 0.125 | 1.03 | 0.56, 1.92 | 0.916 | – | – | – |
| Blonanserin | 1.59 | 0.87, 2.88 | 0.126 | 2.75 | 0.60, 12.64 | 0.193 | – | – | – |
| Brexpiprazole | 0.95 | 0.61, 1.50 | 0.853 | 1.22 | 0.47, 3.12 | 0.683 | 3.41 | 0.93, 12.54 | 0.065 |
| Cariprazine | 1.29 | 0.92, 1.80 | 0.135 | 1.42 | 0.45, 4.52 | 0.552 | 1.38 | 0.75, 2.55 | 0.305 |
| Chlorpromazine | 0.2 | 0.04, 1.08 | 0.061 | – | – | — | – | – | – |
| Clozapine | 0.41 | 0.81, 2.11 | 0.29 | 14.29 | 4.58, 44.55 | 0.000* | – | – | – |
| Fluphenazine | 10.84 | 0.57, 204.0 | 0.111 | – | – | – | – | – | – |
| Flupentixol | – | – | – | 1.41 | 0.10, 19.27 | 0.795 | – | – | – |
| Haloperidol | 1.21 | 0.91, 1.60 | 0.193 | 1.9 | 1.12, 3.22 | 0.017* | 2.61 | 1.14, 5.99 | 0.024* |
| Iloperidone | 0.41 | 0.11, 1.63 | 0.208 | 1.62 | 0.59, 4.48 | 0.351 | 1.46 | 0.76, 2.81 | 0.255 |
| Lurasidone | 0.95 | 0.61, 1.49 | 0.828 | 2.25 | 1.28, 3.97 | 0.005* | 2.63 | 1.57, 4.41 | 0.000* |
| Olanzapine | 0.67 | 0.52, 0.85 | 0.001* | 2.61 | 1.82, 3.75 | 0.000* | 3.26 | 1.87, 5.69 | 0.000* |
| Olanzapine LAI | 0.74 | 0.40, 1.36 | 0.341 | 2.34 | 0.96, 5.72 | 0.062 | – | – | – |
| Paliperidone | 0.81 | 0.57, 1.17 | 0.264 | 1.25 | 0.74, 2.11 | 0.399 | – | – | – |
| Paliperidone LAI | 0.96 | 0.63, 1.45 | 0.854 | 12.18 | 1.15, 128.30 | 0.037* | – | – | – |
| Perphenazine | 1.21 | 0.83, 1.77 | 0.314 | 2.26 | 1.17, 4.39 | 0.015* | 5.33 | 1.92, 14.83 | 0.001* |
| Perospirone | 0.56 | 0.24, 1.31 | 0.184 | 1.19 | 0.20, 7.18 | 0.846 | – | – | – |
| Quetiapine | 0.83 | 0.60, 1.16 | 0.292 | 2.72 | 1.57, 4.71 | 0.000* | 5.14 | 2.07, 12.73 | 0.000* |
| Risperidone | 1.16 | 0.92, 1.47 | 0.21 | 2.09 | 1.24, 3.51 | 0.005* | 2.41 | 1.21, 4.80 | 0.012* |
| Risperidone LAI | 1.08 | 0.74, 1.58 | 0.669 | 4.42 | 1.21, 16.08 | 0.024* | – | – | – |
| Sertindole | 0.84 | 0.32, 2.21 | 0.728 | 2.2 | 0.60, 8.11 | 0.236 | – | – | – |
| Ziprasidone | 1.56 | 1.18, 2.06 | 0.002* | 1.79 | 1.06, 3.02 | 0.029* | 3.64 | 1.92, 6.91 | 0.000* |
| Zotepine | 0.83 | 0.34, 2.04 | 0.686 | 4.3 | 1.91, 9.66 | 0.000* | – | – | – |
*p < 0.05.