TABLE 1.

Comparison of the components of different MSCs’ secretome.

Function	Marker	WJ-MSCs a	AD-MSCs b	BM-MSCs c	DP-MSCs d	Peripheral MSCs e
Angiogenesis							ANG		✓	✓
	ANGPT1	✓	✓	✓	✓
Chemokine	CCT8	✓
	CCL5	✓		✓
	MCP1	✓	✓
	MIP-1B	✓
	SDF-1	✓		✓	✓
Cytokine	IFN-g	✓		✓	✓
	IL-10	✓		✓	✓
	IL-12	✓
	IL-15	✓
	IL-1a	✓	✓	✓
	Il-1b	✓	✓
	IL-2	✓
	IL-4		✓	✓
	IL-6		✓	✓	✓	✓
	IL-7	✓
	IL8	✓	✓
Cytoskeleton	ACTA2	✓	✓	✓	✓	✓
	ACTB	✓	✓	✓	✓	✓
	ACTC1	✓	✓	✓	✓	✓
	ACTG2	✓
	ACTN4	✓	✓
	DES	✓
	FLNA	✓
	SPTA1	✓
	SPTB	✓
	TAGLN	✓
	TPM2	✓
	TUBB	✓
	VIM	✓	✓
ECM protein	FBN1	✓	✓
	FN1	✓	✓
Enzyme	GAPDH	✓
	IDO					✓
Functional protein	MYH11	✓
	MYH14	✓
	MYH9	✓
	MYL6	✓
	TLN1	✓
Growth factor	FGF-2	✓	✓	✓	✓
	GDF6			✓
	GM-CSF	✓
	HGF	✓	✓		✓
	NGF				✓
	PDGF-1		✓	✓	✓
	TGF-B	✓	✓	✓	✓
	VEGF	✓	✓	✓	✓	✓
Hemoglobin	HBA1	✓
	HBB	✓
	HBG2	✓
Hormone	IGF-1	✓	✓	✓		✓
Immune system	IGHG2	✓
	IGHG3	✓
	IGHM	✓
	IGKC	✓
	IGLC2	✓
Inflammation	ANXA1	✓
Inhibitor	TIMP2		✓	✓		✓
lipid metabolism	APOA1	✓
Membrane skeletal protein	ANK1	✓
Nucleoprotein	AHNAK	✓
plasma membrane protein	SLC4A1	✓
Plasma protein	FGB	✓
	A2M	✓
	ALB	✓	✓	✓	✓	✓
	C3	✓
	TF	✓
Pleiotropic protein	ANXA2	✓
Prostaglandin	PGE2	✓
Ribosomal protein	RPLP2	✓
Serine protease inhibitor	SERPINA1	✓	✓	✓
References		Bakhtyar et al., (2018), Mirabdollahi et al., (2019), Konala et al., (2020), Yoo et al., (2009); Prasanna et al., (2010)	Chang et al., (2017), Mussano et al., (2017), An et al., (2021), Chen et al., (2022)	Oskowitz et al., (2011), Katagiri et al., (2017), Baberg et al., (2019), Konala et al., (2020)	Rajan et al., (2017), Konala et al., (2020)	van Buul et al., (2012), Katagiri et al., (2016)

A2M, Alpha-2-Macroglobulin; ACTA2, Actin; aortic smooth muscle; ACTB, Actin; cytoplasmic 1; ACTC1, Actin; alpha cardiac muscle; ACTG2, Actin; gamma-enteric smooth muscle; “ACTN4, Actinin Alpha 4”; AHNAK, Desmoyokin, ALB, Albumin; ANG, Angiogenin; ANGPT1, Angiopoietin-1; ANK1, Ankyrin 1; ANXA1, Annexin A1; ANXA2, Annexin A2; APOA1, Apolipoprotein A1; C3, Complement C3; CCL5, RANTES; CCT8, Chaperonin Containing T-Complex Polypeptide 1 Subunit 8; DES, Desmin; FBN1, Fibrillin 1; FGB, Fibrinogen Beta Chain; FGF-2, Fibroblast growth factor 2; FLNA, isoform 2 of filamin-A; FN1, Fibronectin 1; GAPDH, Glyceraldehyde-3-Phosphate Dehydrogenase; GDF6, Growth Differentiation factor 6; GM-CSF, Granulocyte-Macrophage Colony-Stimulating Factor; HBA1, Hemoglobin Subunit Alpha 1; HBB, Hemoglobin Subunit Beta; HBG2, Hemoglobin Subunit Gamma 2; HGF, Hepatocyte Growth factor; IDO, Indoleamine 2; 3-Dioxygenase 1; IFN-g, Interferon g; IGF-1, Insulin-like growth factor-1; IGHG2, Immunoglobulin Heavy Constant Gamma 2; IGHG3, Immunoglobulin Heavy Constant Gamma 3; IGHM, Immunoglobulin Heavy Constant Mu; IGKC, Immunoglobulin Kappa Constant; IGLC2, Immunoglobulin Lambda Constant 2; IL-10, Interleukin-10; IL-12, Interleukin-12; IL-15, Interleukin-15; IL-1a, Interleukin-1a; Il-1b, Interleukin-1b; IL-2, Interleukin-2; IL-6,; IL-7, Interleukin-7; IL8, Interleukin-8; MCP1, Monocyte Chemoattractant Protein-1; MIP-1B, Macrophage Inflammatory Protein 1-Beta; MYH11, Isoform 2 of Myosin 11; MYH14, Myosin Heavy Chain 14; MYH9, Myosin Heavy Chain 9; MYL6, Myosin Light Chain 6; NGF, Nerve Growth Factor; PDGF-1, Platelet Derived Growth Factor Subunit A; PGE2, Prostaglandin E2; RPLP2: Ribosomal Protein Lateral Stalk Subunit P2, SDF-1: Stromal Cell-Derived Factor 1; SERPINA1, Serpin Family A Member 1; SLC4A1, Solute Carrier Family 4 Member 1; SPTA1, Spectrin Alpha; Erythrocytic 1; SPTB, Spectrin Beta Chain; Erythrocytic; TAGLN, Transgelin; TF, Transferrin; TGF-B, Transforming growth factor b; TIMP2, Tissue Inhibitor Of Metalloproteinases 2; TLN1, Talin 1; TPM2, Tropomyosin 2; TUBB, Tubulin Beta Class I; VEGF, Vascular Endothelial Growth Factor; VIM, Vimentin.

^a Wharton’s jelly mesenchymal stem cells.

^b Adipose tissue mesenchymal stem cells.

^c Bone marrow mesenchymal stem cells.

^d Dental pulp mesenchymal stem cells.

^e Peripheral blood mesenchymal stem cells.

The ✓sign implies the existence of the marker.