FIGURE 5.

Previous pregnancy loss, body mass index (BMI), primary or secondary infertility, and reproductive tract microbial community types (eight panels) in infertile women undergoing an ART procedure. The figure matrix (NMDS1 vs NMDS2) displays the OTU composition of the individual women on two‐dimensional plane, each woman being presented as an individual datapoint. Women experiencing primary (symbols in green) or secondary (symbols in orange) infertility according to previous pregnancy loss (circle – no previous pregnancy loss; triangle – no data; square – previous pregnancy loss) and their BMI (the bigger the symbol, the heavier the woman). BMI categories: 0, no data; 1, <18.5 kg/m² (underweight); 2, 18.5–24.9 kg/m² (normal weight); 3, 25–29.9 kg/m² (overweight); 4, ≥30 (class I & II obesity). PERMANOVA analysis revealed several associations: microbial community type was significantly associated with women's previous pregnancy loss status (Pr[>F] 0.0417) and primary infertility type was significantly associated with elevated BMI (Pr[>F] 0.0201). ART, assisted reproductive technologies; BMI, body mass index; OTU, operational taxonomic unit.