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FRET-based competition assay of KEAP1-targeting PROTACs. All measurement was performed in triplicate and Ki values are expressed as the mean ± standard deviation.
| Compound | Molecular weight (g/mol) | Ki value (nM) | R2 |
|---|---|---|---|
| SD2267 | 920.05 | 57.7 ± 17.5 | 0.94 |
| SD2268 | 920.05 | 8151.7 ± 5707.6 | 0.75 |
| SD2269 | 863.94 | 64.8 ± 13.2 | 0.94 |
