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Pharmacokinetic parameters of SD2267 following IP or PO administrations of SD-2267 (3 mg/kg) in mice (n = 3). Data are expressed as the mean ± SD, except for Tmax, which is presented as median values with range.
| Parameter | SD2267 |
|
|---|---|---|
| IP | PO | |
| Tmax (min) | 80 [60–120] | 80 [60–120] |
| Cmax (μg/mL) | 1.97 ± 0.87 | 0.172 ± 0.116 |
| AUClast (μg·min/mL) | 463 ± 76 | 29.8 ± 8.7 |
| AUC0∼∞ (μg·min/mL) | 468 ± 76 | 35.8 ± 8.5 |
| T1/2 (min) | 220 ± 17 | 739 ± 102 |
| MRT (min) | 290 ± 76 | 727 ± 181 |
