TABLE 1.
Clinical and Demographic Characteristics of Study Subjects
| Total Cohort (N = 50,973; 100%) |
None/Minimal (<1 drink/wk) (n = 23,920; 47%) |
Light/Moderate (1-14 drinks/wk) (n = 27,053; 53%) |
P Value | |
|---|---|---|---|---|
| Age, y | 60 (47, 73) | 59 (46, 72) | 60 (46, 74) | 0.78 |
|
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| Female | 31,113 (61.0) | 15,738 (65.8) | 15,375 (56.8) | <0.0001 |
|
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| Hypertension | 23,744 (46.6) | 11,974 (50.1) | 11,770 (43.5) | <0.0001 |
|
| ||||
| Diabetes | 7,662 (15.0) | 4,776 (20.0) | 2,886 (10.7) | <0.0001 |
|
| ||||
| Hyperlipidemia | 24,006 (47.1) | 11,456 (47.9) | 12,550 (46.4) | 0.001 |
|
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| Current/past smoker | 19,362 (39.9) | 8,807 (38.8) | 10,555 (40.9) | <0.0001 |
|
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| Exercise in METs-min/wk | 1,155 (269, 2,041) | 817 (1, 1,635) | 1,431 (484, 2,378) | <0.0001 |
|
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| Sleep disorders | 13,852 (27.2) | 7,190 (30.1) | 6,662 (24.6) | <0.0001 |
|
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| Depression | 14,115 (27.7) | 7,952 (33.2) | 6,163 (22.8) | <0.0001 |
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| ||||
| Anxiety disorder | 17,205 (33.8) | 8,995 (37.6) | 8,210 (30.4) | <0.0001 |
|
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| Educational level | <0.0001 | |||
| Grade school (1-4 y) | 55 (0.1) | 48 (0.2) | 7 (0.03) | |
| Grade school (5-8 y) | 135 (0.3) | 111 (0.5) | 24 (0.1) | |
| Some high school (9-11 y) | 502 (1.0) | 358 (1.5) | 144 (0.5) | |
| High school diploma | 4,045 (8.0) | 2,628 (11.0) | 1,417 (5.2) | |
| Some college | 5,815 (11.4) | 3,341 (14.0) | 2,474 (9.2) | |
| 2-year college or vocational school | 4,631 (9.1) | 2,709 (11.4) | 1,922 (7.1) | |
| 4-year college | 15,820 (31.1) | 6,635 (27.9) | 9,185 (34.0) | |
| Masters, doctoral, or professional degree | 19,824 (39.0) | 7,992 (33.5) | 11,832 (43.8) | |
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| Employed | 38,407 (75.6) | 17,083 (71.8) | 21,324 (79.0) | <0.0001 |
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| Median income | $84,305 ($65,169, $103,441) | $81,216 ($62,492, $99,941) | $86,080 ($68,108, $104,053) | <0.0001 |
|
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| Charlson index | <0.0001 | |||
| 0 points, 98% 10-y survival | 7,624 (15.0) | 3,222 (13.5) | 4,402 (16.3) | |
| 1 point, 96% 10-y survival | 5,343 (10.5) | 2,420 (10.1) | 2,923 (10.8) | |
| 2 points, 90% 10-y survival | 5,405 (10.6) | 2,385 (10.0) | 3,020 (11.2) | |
| 3 points, 77% 10-y survival | 5,330 (10.5) | 2,428 (10.2) | 2,902 (10.7) | |
| 4 points, 53% 10-y survival | 4,696 (9.2) | 2,099 (8.8) | 2,597 (9.6) | |
| 5 points, 21% 10-y survival | 4,177 (8.2) | 1,913 (8.0) | 2,264 (8.4) | |
| 6 points, 2% 10-y survival | 3,354 (6.6) | 1,531 (6.4) | 1,823 (6.6) | |
| ≥7 points, 0.009% 10-y survival | 14,691 (28.8) | 7,770 (32.5) | 6,921 (25.6) | |
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| PRSss, mean Z-score ± SD | −0.0477 ± 1.0058 | 0.0013 ± 1.0074 | −0.0918 ± 1.0024 | <0.0001 |
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| PRSss, top quintile (%) | 1,747 (20.0) | 900 (21.7) | 847 (18.4) | <0.0001 |
Values are median (Q1, Q3), n (%), or mean ± SD, unless otherwise indicated. P values are reported from chi-square for categorical and Wilcoxon Mann-Whitney test for continuous variables. MET = metabolic equivalence of task; PRSss = polygenic risk score for neuroticism (a genetic index for stress sensitivity).