. Author manuscript; available in PMC: 2024 Jun 20.

Published in final edited form as: J Am Coll Cardiol. 2023 Jun 20;81(24):2315–2325. doi: 10.1016/j.jacc.2023.04.015

Table 2.

Alcohol Consumption vs Stress-Associated Neural Network Activity

Linear Regression Models	n	Standardized Beta (95% CI) for Light/Moderate vs None/Minimal Alcohol Consumption	P Value
Model 1	713	−0.192 (−0.338 to −0.046)	0.010
Model 2	695	−0.202 (−0.352 to −0.052)	0.008
Model 3	698	−0.190 (−0.337 to −0.042)	0.012
Model 4	713	−0.189 (−0.335 to −0.043)	0.011
Model 5	378	−0.206 (−0.395 to −0.016)	0.034

Dependent variable: stress-associated neural network activity measured as amygdalar/ventromedial prefrontal cortex standardized uptake values. Independent variable: Alcohol consumption (light/moderate vs none/minimal). Model 1: linear regression adjusted for age and sex. Model 2: model 1 + socioeconomic factors (education + employment + income). Model 3: model 1 + lifestyle factors (exercise + smoking). Model 4: model 1 + Charlson index (medical comorbidities). Model 5: model 1 + PRSss (polygenic risk score for neuroticism).