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. 2023 Jun 1;19(7):e11267. doi: 10.15252/msb.202211267

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© 2023 The Authors. Published under the terms of the CC BY 4.0 license.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure EV6 — A
Number of metabolites detected per sample in the targeted metabolomics experiment.

B
Distribution of intensities of consistently detected‐ and partially detected metabolites showing an intensity‐dependent detection pattern.

C
PCA plot for all samples in the metabolomics experiment.

D
Significantly affected metabolites due to etoposide treatment and 24‐h release in U2‐ OS sgPRDX1 cells.

E, F
PRDX1 deficiency‐dependency and etoposide treatment‐dependency of analyzed metabolites, based on linear regression analysis on the Untreated – 0 h (E) and 8–24 h release timepoints (F).

G
Differential gene essentiality between high and low PRDX1‐expressing cell lines (CCLE) as in the Achilles dataset. Cell lines with low PRDX1 expression are significantly more sensitive to the depletion of genes represented in the right part of the x‐axis as compared to cell lines with high PRDX1 expression.