Table 2.
Diagnostic Capabilities of Biomarker Expression on CTCs Cell Area.
| Biomarker | Biomarker cell area in HCC | Biomarker cell area in LC | AUC | 95% confidence interval | Youden Index | P-value |
|---|---|---|---|---|---|---|
| EpCAM | 301.1 ± 75.3 | 272.6 ± 61.9 | 0.67 | 0.52–0.84 | 89.34 | 0.031∗ |
| CK | 538.4 ± 323.9 | 418.79 ± 168.9 | 0.59 | 0.41–0.77 | 100.9 | 0.327 |
| AFP | 301.9 ± 247.8 | 420.4 ± 215.5 | 0.47 | 0.26–0.69 | 261.8 | 0.812 |
| EpCAM + CK | 333.5 ± 132.2 | 393.2 ± 156.1 | 0.57 | 0.38–0.76 | 290.3 | 0.475 |
| EpCAM + CK + AFP | – | – | 0.92 | 0.79–1.062 | 150 | <0.001∗ |
AFP, alpha-fetoprotein; AUC, area under the curve; CK, cytokeratin; CTC, circulating tumor cells; EpCAM, epithelial cell adhesion molecule; HCC, hepatocellular carcinoma; LC, liver cirrhosis.
∗Significance P < 0.05.