Table 3.
Demographic Features of Breast Cancer Patients and Their Association with BRCA1 Promoter Methylation in Peripheral Blood Cells
| Parameters | Total 74 (%) |
Me(+)a 2 (%) |
Me(-)b 72 (%) |
p-value | |
|---|---|---|---|---|---|
| Age | ˂50 | 38 (51.4) | 2 (5.3) | 36 (94.7) | |
| 50≤ | 36 (48.6) | 0 (0) | 36 (100) | 0.494 | |
| Menopausal status | Pre | 44 (59.5) | 2 (4.5) | 42 (95.5) | |
| Post | 30 (40.5) | 0 (0) | 30 (100) | 0.511 | |
| Age at menopause |
˂50 | 2 (6.7) | 0 (0) | 2 (100) | |
| 50≤ | 28 (93.3) | 0 (0) | 28 (100) | - | |
| Age at menarche |
≤12 | 49 (66.2) | 0 (0) | 49 (100) | |
| 13-14 | 24 (32.4) | 2 (8.3) | 22 (91.7) | 0.129 | |
| 15≤ | 1 (1.4) | 0 (0) | 1 (100) | ||
| Marriage | Yes | 57 (77) | 0 (0) | 57 | |
| No | 17 (23) | 2 (11.8) | 15 (88.2) | 0.05 | |
| Child number | ˂2 | 24 (32.4) | 2 (8.3) | 22 (91.7) | |
| 2≤ | 50 (67.6) | 0 (0) | 50 (100) | 0.102 | |
| Breastfeeding | Yes | 43 (58.1) | 0 (0) | 43 (100) | |
| No | 31 (41.9) | 2 (6.5) | 29 (93.5) | 0.172 | |
| Age at first pregnancy | ˂ 30 | 55 (74.3) | 0 (0) | 55 | |
| 30≤ | 2 (2.7) | 0 (0) | 2 | 0.104 | |
| Nulliparity | 17 (23) | 2 (11.8) | 15 (88.2) | ||
a, Me(+): BRCA1 promoter methylation positive in peripheral cells; b, Me(-): BRCA1 promoter methylation negative in peripheral cells