Table 4.
Distribution of IDH Mutation in cfDNA and FFPE Tumor Tissue of ADG
| Adult-type diffuse glioma | WHO Grade | IHC-IDH (MT/WT) |
CAST-PCR-IDH (MT/WT) |
Mean cfDNA (ng/mL) |
IDH in cfDNA (MT/WT) |
|---|---|---|---|---|---|
| Astrocytoma IDH-mutant | Grade 2 (n=6) | 6/0 | 6/0 | 280.80±361.80 | 0/6 |
| Grade 3 (n=4) | 4/0 | 4/0 | 79.57±50.55 | 0/4 | |
| Grade 4 (n=1) | 1/0 | 1/0 | 66.70±0.00 | 0/1 | |
| Oligodendroglioma IDH-mutant 1p19q co-deleted |
Grade 2 (n=7) | 7/0 | 7/0 | 151.50±143.90 | 1/6 |
| Grade 3 (n=3) | 3/0 | 3/0 | 293.20±203.20 | 1/2 | |
| Glioblastoma IDH-wildtype | Grade 4 (n=24) | 0/24 | 5/19 | 394.80±626.90 | 1/23 |